[Transperancy/Accountability] Proteins folded so far.

Message boards : Rosetta@home Science : [Transperancy/Accountability] Proteins folded so far.

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Message 45379 - Posted: 25 Aug 2007, 9:42:06 UTC
Last modified: 25 Aug 2007, 10:13:45 UTC

All proteins have names. For example,

Protein name: Protein phosphatase 1 regulatory subunit 1B
Synonyms: Dopamine- and cAMP-regulated neuronal phosphoprotein
DARPP-32

Gene name: PPP1R1B
Synonyms: DARPP32

taken from the protein database at: http://www.expasy.org/uniprot/Q9UD71

Could someone please list the names of the proteins folded so far by this project. Thank you.
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Message 45380 - Posted: 25 Aug 2007, 10:09:05 UTC
Last modified: 25 Aug 2007, 10:10:35 UTC

Why do you want a list? just email them and you may give you it.

But transparent ? Why would you not want to look at the project, if it was transparent wouldn't that mean you look straight through the project and out the other side and not see anything ?

(opaque may be or translucent, though the latter probably makes it a bit fuzzy ;)

As far as I know you can get what you are doing from the task name.


Unfortunatly the 'results' on the front page doesn't seem to be working at the moment so you cannot easily see all of what is being worked on.
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Message 45385 - Posted: 25 Aug 2007, 10:27:14 UTC - in response to Message 45380.  
Last modified: 25 Aug 2007, 10:27:52 UTC

Why do you want a list? just email them and you may give you it.
But transparent ? Why would you not want to look at the project, if it was transparent wouldn't that mean you look straight through the project and out the other side and not see anything ?
(opaque may be or translucent, though the latter probably makes it a bit fuzzy ;)
As far as I know you can get what you are doing from the task name.


The point is that other scientists can view the complete results of the folded protein and so can we.

Dr. Baker isn't going to write an article on every protein that is folded.
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Message 45397 - Posted: 25 Aug 2007, 13:55:43 UTC

Or, if you were on the Project Team and you wished to be "accountable" to your contributors, you could just create a thread where you list them, then create a PROJECT INFORMATION AND HELP INDEX with a link to it, and place a sticky thread to this on each of the 3 main message boards.

...so, next time, asking the question "Are the proteins listed anywhere?" before raising words like transperancy, would be a great idea.

Rosetta is a research project. They study how to do the predictions better. And so as they devise new schemes to create more accurate models, then end up running against many of the same proteins again to measure the success of the new approach as compared to what they had before. So, it's not like they are starting with a list of 10,000 proteins and just crunching their way through it. So it makes it difficult to really describe what they have "completed".

If BakerLab packs up and goes home, it is because they have completed a computer program that can predict any protein (or RNA strand, or amyloid fibrils) and it's interactions with another protein (i.e. docking) perfectly. But that eventuality would require some breakthroughs in physics or in understanding of subatomic forces. These outcomes are unlikely to occur in our lifetimes. And so we are left with a computer program that doesn't reach a perfect prediction, and it works better on some proteins then others. But it continues to be the best that mankind has to use for drug design and modeling of these objects.
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Message 45424 - Posted: 25 Aug 2007, 19:23:33 UTC - in response to Message 45385.  

Why do you want a list? just email them and you may give you it.
But transparent ? Why would you not want to look at the project, if it was transparent wouldn't that mean you look straight through the project and out the other side and not see anything ?
(opaque may be or translucent, though the latter probably makes it a bit fuzzy ;)
As far as I know you can get what you are doing from the task name.


The point is that other scientists can view the complete results of the folded protein and so can we.

Dr. Baker isn't going to write an article on every protein that is folded.


That's a much nicer phrased question in the first post now :D

We're not virtual screening as such here...
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Message 46009 - Posted: 11 Sep 2007, 17:46:32 UTC - in response to Message 45397.  

Or, if you were on the Project Team and you wished to be "accountable" to your contributors, you could just create a thread where you list them, then create a PROJECT INFORMATION AND HELP INDEX with a link to it, and place a sticky thread to this on each of the 3 main message boards.

...so, next time, asking the question "Are the proteins listed anywhere?" before raising words like transperancy, would be a great idea.

Rosetta is a research project. They study how to do the predictions better. And so as they devise new schemes to create more accurate models, then end up running against many of the same proteins again to measure the success of the new approach as compared to what they had before. So, it's not like they are starting with a list of 10,000 proteins and just crunching their way through it. So it makes it difficult to really describe what they have "completed".

If BakerLab packs up and goes home, it is because they have completed a computer program that can predict any protein (or RNA strand, or amyloid fibrils) and it's interactions with another protein (i.e. docking) perfectly. But that eventuality would require some breakthroughs in physics or in understanding of subatomic forces. These outcomes are unlikely to occur in our lifetimes. And so we are left with a computer program that doesn't reach a perfect prediction, and it works better on some proteins then others. But it continues to be the best that mankind has to use for drug design and modeling of these objects.


Rosetta@home Active WorkUnit(s) Log has not been updated since April 2007. Why isn't Rosetta@home folding the Protein name: Protein phosphatase 1 regulatory subunit 1B (Synonyms: Dopamine- and cAMP-regulated neuronal phosphoprotein
DARPP-32 Gene name: PPP1R1B Synonyms: DARPP32) as this is the main protein which can lead to scientific breakthroughs.
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Message 46014 - Posted: 11 Sep 2007, 18:14:24 UTC

as this is the main protein which can lead to scientific breakthroughs.

Justify that.
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Message 46989 - Posted: 25 Sep 2007, 19:03:54 UTC - in response to Message 46014.  

as this is the main protein which can lead to scientific breakthroughs.

Justify that.


just read the post of mod sense, the you should know not to ask these kind of questions. now rosetta is just working on becoming a program that works for all protein related stuff, on its way to become that, it needs to work on protein's so most likely they pick protein's of wich they know what should come up after crunching, so they can see if it works perfectly.
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Message 47012 - Posted: 26 Sep 2007, 8:58:04 UTC

I know exactly what R@H is trying to do. It was your contention that
Protein phosphatase 1 regulatory subunit 1B (Synonyms: Dopamine- and cAMP-regulated neuronal phosphoprotein DARPP-32 Gene name: PPP1R1B Synonyms: DARPP32)

is
the main protein which can lead to scientific breakthroughs.


There are major breakthroughs to be made with many proteins. I asked you to justify your contention that this one is the "main" one.

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Message boards : Rosetta@home Science : [Transperancy/Accountability] Proteins folded so far.



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