That really should be placed (probably by the moderator) in a sticky entitled "Research Highlights" or something like that, so that it is easily accessible and does not get lost. A significant result like that can not be expected all the time, but it is very encouraging when it happens.

Thanks for the update.

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That really should be placed (probably by the moderator) in a sticky entitled "Research Highlights" or something like that, so that it is easily accessible and does not get lost. A significant result like that can not be expected all the time, but it is very encouraging when it happens.

+1

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This sounds really exciting! Thanks for posting the update, Anastassia. Quick question - approximately how many models did you run on Rosetta@home for the validation process?

I fully agree that this forum needs a research highlights channel, or maybe they just need to be added to a thread in "News" that has links to all of the research posts?

Also, here are the formatted links:
https://www.bakerlab.org/index.php/2018/09/12/de-novo-fluorescent-proteins/
https://cen.acs.org/physical-chemistry/periodic-table/Designer-protein-tackles-binding/96/i37
http://www.sciencemag.org/news/2018/09/watch-these-new-designer-proteins-light-when-they-hit-their-target

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Congratulations!

Keep the good work!

Thank you, for sharing this success story. As a CPU volunteer, I often wonder at the results; though, I have never taken the time to search things out before. This COVID-19 Pandemic has given me a bit more time to explore...and, perhaps, to slow down a bit.

Thanks, again!
ChrysBlaze

Thanks for the positive feedback! We ran validation on Rosetta@home for 60-70 models for the first part of the work (the design of the fold, experimenting with different approaches) then another 50 designs with ligand-binding cavity.

Many thanks, to giving us insight to your project. Sounds really interesting and promising. Hope you will use Rosetta again for your work!

This appears to be related - via @UWProteinDesign on twitter
In a new report, we describe the de novo design & characterization of selective ion channels, as well as larger pores that permit the passage of fluorescent molecules thru cell walls.

Computational design of transmembrane pores | @nature
#ProteinDesign

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